It is known that there is a serious increase in the incidence of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis and Spinocerebellar Ataxias in our country and all over the world. In addition to the increasing frequency of diseases, reasons such as epidemics, the aging population, and the lack of medical specialists lead to an increase in the burden on the health system and personnel. Today, there is no effective treatment for many neurodegenerative diseases. Therefore, physiotherapy and rehabilitation approaches are very important for the symptom management of diseases. In addition, considering the physical limitations, communication difficulties, transportation and accessibility problems, cognitive influences, financial limitations and psychological factors in these disease groups create barriers for patients to access and continue physiotherapy and rehabilitation services. As a solution to these problems, approaches that allow remote assessment, rehabilitation and follow-up and involve the participant in rehabilitation with lower cost and simple interface systems are needed. In today's world where digital transformation in health is gaining momentum, information systems integrated into health services can increase quality and efficiency, reduce costs and provide the opportunity to deal with more patients with the same resources; therefore, it contributes to the economy by reducing costs both individually and socially. For all these reasons, within the scope of our project, we aim to develop the NÖRALSİS-Virtual Clinic, which allows biosensor assisted tele-assessment and tele-rehabilitation of people with neurodegenerative diseases. The architecture of the NÖRALSİS-Virtual Clinic, which includes two different panels for the clinician and the patient, will be created, and wearable biosensors for tele-assessment and tele-monitoring will be integrated into the system. Through the clinician's panel, it will be possible for the clinician to monitor patient data, perform synchronous and asynchronous tele-assessment and tele-rehabilitation, and access patient reports. Through the sections in the patient panel, patients will have access to their personal information, assessment results, exercise program prepared by their clinician, and their upcoming appointments. An artificial intelligence-based decision support algorithm will be created within the scope of NÖRALSİS-Virtual Clinic. Through wearable biosensors, objective data on heart rate, blood pressure, body temperature, electrodermal activity and postural sway will be collected to detect and monitor deviations from normal in physiological and physical parameters. Data obtained from patients through wearable biosensors will be used to develop the artificial intelligence-based decision support system, thus providing an individualized rehabilitation service that can produce analytical solutions. A total of 50 patients will be included in the project and the patients will be trained about the NÖRALSİS-Virtual Clinic. Patients will be evaluated first in a face-to-face clinic and then on a synchronous, asynchronous and biosensor-based basis through the tele-assessment portal in the system. A personalized treatment program will be created based on the evaluation data, and patients will be followed remotely by the clinician, both synchronously and asynchronously. When the determined rehabilitation program is completed, the evaluations will be repeated and feedback on system usability will be received from patients and clinicians. With the NÖRALSİS-Virtual Clinic, health expenditures will be reduced by integrating with wearable biosensors that will provide tele-assessment, tele-rehabilitation and tele-monitoring by removing the restrictions on the access and adherence of patients. This system will set an example and pioneering approach to the remote treatment and monitoring system in health.