Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of <i>Allium cepa</i> root tips
ACTA BIOLOGICA HUNGARICA, vol.59, no.1, pp.93-102, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 1
- Publication Date: 2008
- Doi Number: 10.1556/abiol.59.2008.1.8
- Journal Name: ACTA BIOLOGICA HUNGARICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.93-102
- Istanbul Kültür University Affiliated: Yes
Abstract
The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine ( Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, alpha-difluoromethylornithine ( DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) ( MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.