ASSOCIATION OF PERIPHERAL VISFATIN LEVELS AND VISFATIN G-948T GENE POLYMORPHISM WITH ALZHEIMER'S DISEASE IN A TURKISH POPULATION

Vurgun U., ŞAHİN Ö., TÜFEKCİ K. U., KESKİNOĞLU P., YENER G., GENÇ K. K., ...Daha Fazla

TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, cilt.16, sa.2, ss.123-128, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.123-128
  • İstanbul Kültür Üniversitesi Adresli: Hayır

Özet

Introduction: Visfatin is a pleiotropic cytokine implicated in several physiological and pathophysiological processes such as innate immunity, cellular metabolism, longevity, and inflammation. Altered visfatin levels and visfatin gene polymorphisms have been reported in various human diseases, including type 2 diabetes mellitus, rheumatoid arthritis, obesity, coronary artery disease and stroke.. Materials and Method: In this study, we investigated whether serum visfatin levels were changed in volunteers with Alzheimer's disease (AD) (n = 40) or healthy controls (n=40) and whether visfatin gene G-948T polymorphism was associated with the disease. Results: Visfatin levels were not significantly different in AD patients compared with healthy aged control subjects. In this relatively small population, we found a significant, but weak association between GT heterozygous genotype at position -948 of visfatin gene and AD. However, there was no association between G-948T polymorphism and visfatin levels, and any demographic, anthropometric or biochemical parameters. Conclusion: Further studies in larger and different populations are needed to fully elaborate the involvement of visfatin gene in AD.