Molecular Mechanics Studies of Antihypertensive Val-Tyr Dipeptide

Akverdieva G. A., Godjayev N. M., AKYÜZ S., Akyuz T., Dogan N. E.

ASIAN JOURNAL OF CHEMISTRY, vol.22, no.1, pp.311-318, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2010
  • Journal Name: ASIAN JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.311-318
  • Istanbul Kültür University Affiliated: Yes

Abstract

The spatial structure of anti hypertensive dipeptide,Valine-Tyrosine was investigated within molecular mechanics framework. It ha, been shown that the molecule has such a structural organization which does not exclude the realization of two types of conformation: folded and extended. The energy and geometrical parameters for the optimal conformations of dipeptide are obtained. The electronic characteristics for these structures were analyzed by quantum chemical calculations.