Effect of dietary fibre supplementation on metabolic endotoxemia: a systematic review and meta-analysis of randomised clinical trials

Ranneh Y., Hamsho M., Fadel A., Al Raish S., Ali Ghazzawi H., Hoteit M., ...More

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, vol.77, no.3, pp.212-224, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 77 Issue: 3
  • Publication Date: 2026
  • Doi Number: 10.1080/09637486.2026.2644867
  • Journal Name: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, MEDLINE
  • Page Numbers: pp.212-224
  • Keywords: cytokiens, dietary fibre, lipopolysaccharide, low-grade chronic inflammation, Metabolic endotoxemia
  • Istanbul Kültür University Affiliated: Yes

Abstract

The objective of this systematic review and meta-analysis was to evaluate the impact of dietary fibre (DF) supplementation on metabolic endotoxemia (ME). A comprehensive search of multiple databases was conducted to identify relevant clinical trials. Selected trials were systematically reviewed, and a meta-analysis was performed using a random-effects model. The comprehensive database search retrieved 732 records; of these, 15 randomised controlled trials involving a total of 773 participants fulfilled the eligibility criteria and were subsequently included in the systematic review and meta-analysis. Supplementation with DF significantly decreased serum lipopolysaccharide levels (p < 0.00001, I-2 = 97%). TNF-alpha levels also decreased significantly (p < 0.02, I-2 = 90%), while IL-10 levels increased (p < 0.02, I-2 = 85%). DF supplementation did not significantly affect lipopolysaccharide-binding protein, C-reactive protein, IL-6, HDL, or LDL levels. The pooled evidence provides evidence to support the use of DF supplementation in ameliorating ME and inflammatory cytokines which could prevent chronic inflammation-related diseases.