Effect of dietary fibre supplementation on metabolic endotoxemia: a systematic review and meta-analysis of randomised clinical trials

Ranneh Y., Hamsho M., Fadel A., Al Raish S., Ali Ghazzawi H., Hoteit M., ...Daha Fazla

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, cilt.77, sa.3, ss.212-224, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 77 Sayı: 3
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/09637486.2026.2644867
  • Dergi Adı: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, MEDLINE
  • Sayfa Sayıları: ss.212-224
  • Anahtar Kelimeler: cytokiens, dietary fibre, lipopolysaccharide, low-grade chronic inflammation, Metabolic endotoxemia
  • İstanbul Kültür Üniversitesi Adresli: Evet

Özet

The objective of this systematic review and meta-analysis was to evaluate the impact of dietary fibre (DF) supplementation on metabolic endotoxemia (ME). A comprehensive search of multiple databases was conducted to identify relevant clinical trials. Selected trials were systematically reviewed, and a meta-analysis was performed using a random-effects model. The comprehensive database search retrieved 732 records; of these, 15 randomised controlled trials involving a total of 773 participants fulfilled the eligibility criteria and were subsequently included in the systematic review and meta-analysis. Supplementation with DF significantly decreased serum lipopolysaccharide levels (p < 0.00001, I-2 = 97%). TNF-alpha levels also decreased significantly (p < 0.02, I-2 = 90%), while IL-10 levels increased (p < 0.02, I-2 = 85%). DF supplementation did not significantly affect lipopolysaccharide-binding protein, C-reactive protein, IL-6, HDL, or LDL levels. The pooled evidence provides evidence to support the use of DF supplementation in ameliorating ME and inflammatory cytokines which could prevent chronic inflammation-related diseases.