Akademik Veri Yönetim Sistemi
Journal of the American Nutrition Association, cilt.44, sa.7, ss.1-10, 2025 (SCI-Expanded)
Objectives: Natural products like Aronia (Aronia melanocarpa) are promising candidates to managemetabolic abnormalities due to their bioactive compounds. This study aimed to evaluate the effectsof daily Aronia fruit extract supplementation on the components of Metabolic Syndrome (MetS),cardiovascular health, inflammation, and atherogenic markers in elderly patients.Methods: Our study is a randomized controlled trial of 44 subjects (12 males and 32 females)diagnosed with MetS. The study groups were the intervention group (n = 22), which received daily10 g Aronia fruit extract for 8 wk, and the control group, which did not receive the extract (n = 22).Demographics, dietary intake, and food habits were recorded by an extended survey. Baseline andpost-intervention measurements of anthropometric data, dietary intake, cardiovascular parameters,blood pressure, blood lipid composition, plasma atherogenic index (PAI), triglyceride (TG), and thetriglyceride-glucose index (TyG), and biomarkers of inflammation, including tumor necrosisfactor-alpha (TNF-α), Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and oxidativestress biomarkers, were represented as delta values.Results: No significant changes were observed in anthropometric measurements within or betweengroups over the 8 wk. However, several cardiovascular health parameters, including diastolic bloodpressure (−10.00 mmHg), PAI index (−0.06), triglycerides (−9.0 mg/dL), and low-density lipoproteincholesterol (LDL-C) (−6.30 mg/dL) were significantly decreased in the intervention group comparedto the control group at the end of 8 wk of use (p < 0.05). Inflammatory markers TNF-α (−7.87 pg/mL)and IL-6 (−0.58 pg/mL), as well as oxidative stress markers, oxidized low-density lipoprotein (ox-LDL)(−132.17 U/L) and small dense low-density lipoprotein (sdLDL) (−0.79 mg/dL), also significantlydecreased in the intervention group (p < 0.001).Conclusion: Our findings suggest that daily supplementation with Aronia fruit extract significantlyimproves cardiovascular health markers and reduces inflammation and oxidative stress in elderlypatients with MetS. Hence, Aronia extract may be an effective dietary supplement for managingMetS in high-risk groups