Synthesis of Thieno[2,3-d] pyrimidines via Microwave-Assisted Thermolysis of 1-(Thiophene-2-yl)-1H-tetrazoles

Soares M. I. L., Pinho e Melo T. M. V. D., Fausto R.

CHEMISTRYSELECT, vol.1, no.15, pp.4591-4595, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1 Issue: 15
  • Publication Date: 2016
  • Doi Number: 10.1002/slct.201601196
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4591-4595
  • Istanbul Kültür University Affiliated: Yes

Abstract

A selective and efficient method for the synthesis of unusual thieno[2,3-d] pyrimidines incorporating two thiophene rings via thermal reactions of 1-(thiophene-2-yl)-1H-tetrazoles is reported. Microwave-assisted thermolysis of 1-(thiophene-2-yl)-1H-tetrazoles at 160 8 degrees C in a water/toluene(2:1)solvent system afforded thieno[2,3-d] pyrimidines in moderate to good yield (upto66%) as single products.