Synthesis of Thieno[2,3-d] pyrimidines via Microwave-Assisted Thermolysis of 1-(Thiophene-2-yl)-1H-tetrazoles
CHEMISTRYSELECT, cilt.1, sa.15, ss.4591-4595, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1 Sayı: 15
- Basım Tarihi: 2016
- Doi Numarası: 10.1002/slct.201601196
- Dergi Adı: CHEMISTRYSELECT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4591-4595
- İstanbul Kültür Üniversitesi Adresli: Hayır
Özet
A selective and efficient method for the synthesis of unusual thieno[2,3-d] pyrimidines incorporating two thiophene rings via thermal reactions of 1-(thiophene-2-yl)-1H-tetrazoles is reported. Microwave-assisted thermolysis of 1-(thiophene-2-yl)-1H-tetrazoles at 160 8 degrees C in a water/toluene(2:1)solvent system afforded thieno[2,3-d] pyrimidines in moderate to good yield (upto66%) as single products.