Antioxidant, Enzyme Inhibitor Activities of Amanita ceciliae and Its Effects against A549 Lung Cancer Cell Line
Biology Bulletin, cilt.53, sa.2, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1134/s1062359025614302
- Dergi Adı: Biology Bulletin
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Artic & Antarctic Regions, BIOSIS, Zoological Record, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Anahtar Kelimeler: Amanita ceciliae, anticholinesterase effect, antioxidant activity, antiproliferative effect
- İstanbul Kültür Üniversitesi Adresli: Evet
Özet
Abstract: In this study, antioxidant, anticholinesterase and antiproliferative effects of ethanol extract of Amanita ceciliae (Berk. & Broome) Bas species were evaluated. Antioxidant activity was determined by total antioxidant capacity (TAS), total oxidant level (TOS) and oxidative stress index (OSI) parameters. TAS, TOS and OSI values of the extract were determined as 3.224 mmol/L, 24.215 µmol/L and 0.752, respectively. Anticholinesterase activity was investigated via inhibitory potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes and IC50 values were determined as 118.27 and 207.53 µg/mL, respectively. Antiproliferative activity was evaluated using A549 human lung cancer cell line and it was observed that the extract caused a dose-dependent decrease in cell viability. The findings suggest that Amanitaceciliae has moderate antioxidant capacity, weak anticholinesterase and limited antiproliferative activity. These data provide the basis for further studies to understand the biological potential of the mushroom.